Brain & Cognitive Health
SEMAX
Overview
Semax is a synthetic peptide originally developed for neurological research. It is best known for supporting cognitive performance, memory, focus, and neuroprotection without acting as a stimulant.
How It Works
Semax increases the expression of Brain-Derived Neurotrophic Factor (BDNF) and other growth factors involved in learning, memory, and neuronal repair. It also modulates dopamine and serotonin pathways, helping support cognitive performance and resilience to stress.
Key Benefits
- Supports memory and learning
- Improves concentration and focus
- Promotes mental clarity
- Supports recovery after neurological injury (under medical supervision)
- May reduce mental fatigue
- Neuroprotective properties
Scientific Research
Semax has been studied for cognitive impairment, stroke recovery, and neuroprotection. Research suggests it may improve attention, memory, and neuronal survival, although much of the published clinical work originates from Russia and additional international studies are needed.
Best For
- Memory support
- Students
- Entrepreneurs
- High-performance professionals
- Mental fatigue
SELANK
Selank is a synthetic peptide studied for its calming effects and potential to improve cognitive performance without causing sedation.
Overview
How It Works
Selank influences serotonin, dopamine, and GABA signaling, helping regulate mood, stress response, and cognitive function.
Key Benefits
- Promotes relaxation without drowsiness
- Supports focus during stressful situations
- May improve memory retention
- Helps reduce anxiety symptoms
- Supports emotional balance
Scientific Research
Clinical and experimental studies suggest Selank may reduce anxiety while maintaining cognitive performance. Most human research has been conducted in Russia.
Best For
- Stress management
- Anxiety support
- Mental performance
- High-pressure careers
DIHEXA
What is Dihexa? Dihexa is an investigational peptide designed to promote synapse formation and improve cognitive function.
Overview
How It Works
Dihexa activates pathways involved in neuronal growth and synaptic connectivity, potentially enhancing communication between brain cells.
Key Benefits
- Supports learning and memory
- Promotes neuroplasticity
- May enhance cognitive performance
- Potential neuroregenerative effects
Scientific Research
Animal studies have demonstrated significant improvements in learning and memory. Human clinical research remains limited, and Dihexa is still considered investigational.
Best For
- Cognitive optimization
- Brain health research
- Neuroplasticity support
P21
P21 is an experimental peptide being studied for its potential role in neuronal regeneration and cognitive enhancement.
Overview
How It Works
P21 may stimulate pathways involved in neuronal survival, synaptic function, and brain repair.
Key Benefits
- Supports memory formation
- Promotes neuronal repair
- May improve learning capacity
- Supports brain resilience
Scientific Research
Current evidence comes primarily from preclinical studies investigating Alzheimer's disease and neurodegenerative disorders.
Best For
- Brain longevity
- Memory support
- Neuroregeneration research
CEREBROLYSIN
Overview
Cerebrolysin is a peptide-based neurotrophic therapy composed of low-molecular-weight peptides and amino acids designed to support brain function.
How It Works
It mimics natural neurotrophic factors, supporting neuronal survival, repair, and plasticity.
Key Benefits
- Supports cognitive recovery
- Promotes neuronal repair
- Enhances neuroplasticity
- Supports healthy brain aging
Scientific Research
Cerebrolysin has been evaluated in clinical studies involving stroke recovery, traumatic brain injury, and cognitive impairment. Results have shown potential benefits in selected patient populations, though regulatory approval varies by country.
Best For
- Brain recovery
- Cognitive support
- Healthy aging
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NAD+
Overview
Nicotinamide Adenine Dinucleotide (NAD+) is an essential coenzyme found in every cell of the body and plays a central role in cellular energy production and DNA repair.
How It Works
NAD+ supports mitochondrial function by helping convert nutrients into ATP, the body's primary energy source. It also activates enzymes involved in DNA repair and healthy aging.
Key Benefits
- Increases cellular energy
- Supports mitochondrial health
- Promotes healthy aging
- Enhances mental clarity
- Supports DNA repair
Scientific Research
Declining NAD+ levels are associated with aging. Research suggests restoring NAD+ may improve mitochondrial function and metabolic health, although long-term clinical outcomes continue to be investigated.
Best For
- Energy
- Longevity
- Brain performance
- Cellular health
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MOTS-c
Overview
MOTS-c is a naturally occurring mitochondrial peptide involved in regulating metabolism and cellular energy balance.
How It Works
It enhances insulin sensitivity and helps cells adapt to metabolic stress while improving mitochondrial efficiency.
Key Benefits
- Supports energy metabolism
- Improves insulin sensitivity
- Promotes healthy aging
- Supports exercise performance
Scientific Research
Human and animal studies suggest MOTS-c plays a role in metabolic regulation, exercise capacity, and healthy aging, though ongoing research continues.
Best For
- Metabolic health
- Longevity
- Cellular energy
SS-31 (Elamipretide)
Overview
SS-31, also known as Elamipretide, is a mitochondria-targeting peptide designed to protect cells from oxidative stress and improve mitochondrial function. It has become one of the most promising investigational peptides in longevity and age-related disease research.
How It Works
SS-31 selectively binds to cardiolipin, a phospholipid found in the inner mitochondrial membrane. By stabilizing mitochondrial structure, it improves ATP production, reduces oxidative damage, and enhances cellular energy efficiency.
Key Benefits
- Supports mitochondrial health
- Improves cellular energy production
- Reduces oxidative stress
- Promotes healthy aging
- Supports muscle endurance and recovery
- May help protect brain and heart cells
Scientific Research
SS-31 has been investigated in both animal and human clinical studies for mitochondrial disorders, cardiovascular disease, kidney disease, muscle fatigue, and neurodegenerative conditions. Research suggests improvements in mitochondrial efficiency and reduced cellular damage, although many applications remain investigational.
Best For
- Longevity
- Cellular energy
- Brain health
- Healthy aging
- Recovery
5-Amino-1MQ
Overview
5-Amino-1MQ is an investigational small molecule that inhibits the enzyme Nicotinamide N-methyltransferase (NNMT), an enzyme involved in fat storage and metabolic regulation.
How It Works
By inhibiting NNMT activity, 5-Amino-1MQ may enhance cellular metabolism, increase energy expenditure, and improve the body's ability to utilize stored fat.
Key Benefits
- Supports healthy metabolism
- Promotes fat utilization
- May improve insulin sensitivity
- Supports cellular energy production
- May help preserve lean muscle during weight loss
Scientific Research
Most evidence comes from preclinical studies demonstrating improvements in metabolic health, fat reduction, and insulin sensitivity. Human clinical research is still limited.
Best For
- Metabolic health
- Body recomposition
- Cellular energy
- Longevity support
BPC-157
Overview
BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a naturally occurring protein found in gastric juice. It is widely researched for its regenerative and tissue-healing properties.
How It Works
BPC-157 promotes angiogenesis (the formation of new blood vessels), supports collagen production, and enhances tissue repair. It may also reduce inflammation and support nervous system recovery.
Key Benefits
- Supports muscle and tendon healing
- Promotes ligament recovery
- Supports gut health
- Reduces inflammation
- May support nerve regeneration
- Accelerates tissue repair
Scientific Research
Numerous animal studies have demonstrated significant regenerative effects across muscles, tendons, ligaments, nerves, and the gastrointestinal tract. Human clinical research is still limited, but BPC-157 has gained widespread interest in regenerative medicine.
Best For
- Injury recovery
- Athletes
- Gut health
- Recovery after surgery
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P21
P21 is an experimental peptide being studied for its potential role in neuronal regeneration and cognitive enhancement.
Overview
How It Works
P21 may stimulate pathways involved in neuronal survival, synaptic function, and brain repair.
Key Benefits
- Supports memory formation
- Promotes neuronal repair
- May improve learning capacity
- Supports brain resilience
Scientific Research
Current evidence comes primarily from preclinical studies investigating Alzheimer's disease and neurodegenerative disorders.
Best For
- Brain longevity
- Memory support
- Neuroregeneration research
GHK-Cu (Copper Peptide)
Overview
GHK-Cu is a naturally occurring copper-binding peptide found in human plasma, saliva, and urine. It is best known for its regenerative properties in skin, hair, and connective tissue.
How It Works
GHK-Cu regulates genes involved in tissue repair, collagen production, wound healing, and anti-inflammatory responses. It also acts as a powerful antioxidant.
Key Benefits
- Stimulates collagen production
- Supports skin elasticity
- Improves wound healing
- Promotes hair growth
- Reduces inflammation
- Supports tissue regeneration
Scientific Research
Research spanning several decades has demonstrated GHK-Cu's role in tissue repair, skin rejuvenation, wound healing, and hair follicle regeneration. Emerging studies also suggest neuroprotective and anti-aging potential.
Best For
- Skin rejuvenation
- Hair health
- Healthy aging
- Recovery
DSIP
Overview
Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring neuropeptide studied for its potential role in regulating sleep quality, stress response, and recovery.
How It Works
Although its exact mechanism remains under investigation, DSIP appears to influence neuroendocrine function and may help regulate sleep cycles and stress hormones.
Key Benefits
- Supports restorative sleep
- May reduce stress levels
- Promotes physical recovery
- Supports nervous system balance
- May improve overall well-being
Scientific Research
Research on DSIP has produced mixed results. While some studies suggest improvements in sleep quality and stress regulation, larger clinical trials are needed to fully establish its therapeutic role.
Best For
- Sleep optimization
- Recovery
- Stress management
- Overall wellness
Epitalon
What is Epitalon? Epitalon is a synthetic tetrapeptide developed from Epithalamin, a naturally occurring peptide produced by the pineal gland. It is widely researched for its potential role in healthy aging and longevity.
Overview
How It Works
Epitalon is believed to activate telomerase, the enzyme responsible for maintaining telomere length, while also supporting melatonin production and reducing oxidative stress.
Key Benefits
- Supports healthy aging
- Promotes cellular regeneration
- Supports sleep quality
- Reduces oxidative stress
- May support immune function
- Supports long-term cellular health
Best For
- Longevity
- Healthy aging
- Sleep support